Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism

PURPOSE: Dopamine receptor D2 (DRD2) is a G protein-coupled receptor antagonized by ONC201, an anti-cancer small molecule in clinical trials for high grade gliomas and other malignancies. DRD5 is a dopamine receptor family member that oppose DRD2 signaling. We investigated the expression of these do...

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Udgivet i:Clin Cancer Res
Main Authors: Prabhu, Varun V., Madhukar, Neel S., Gilvary, Coryandar, Kline, C. Leah B., Oster, Sophie, El-Deiry, Wafik S., Elemento, Olivier, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Tarapore, Rohinton S., Deacon, Sean, Charter, Neil, Jung, Jinkyu, Park, Deric M., Gilbert, Mark R., Rusert, Jessica, Wechsler-Reya, Robert, Arrillaga-Romany, Isabel, Batchelor, Tracy T., Wen, Patrick Y., Oster, Wolfgang, Allen, Joshua E.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259201/
https://ncbi.nlm.nih.gov/pubmed/30559168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2572
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