Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA) thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H(2)O(2)). We show that MAO metabolism of DA does not increase cytosolic H(2)O(2), but leads to mitochondrial electron transport chain (ETC) activ...

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Publicado en:Nat Neurosci
Main Authors: Graves, Steven M., Xie, Zhong, Stout, Kristen A., Zampese, Enrico, Burbulla, Lena F., Shih, Jean C., Kondapalli, Jyothisri, Patriarchi, Tomasso, Tian, Lin, Brichta, Lars, Greengard, Paul, Krainc, Dimitri, Schumacker, Paul T., Surmeier, D. James
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7257994/
https://ncbi.nlm.nih.gov/pubmed/31844313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0556-3
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