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Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain
Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA) thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H(2)O(2)). We show that MAO metabolism of DA does not increase cytosolic H(2)O(2), but leads to mitochondrial electron transport chain (ETC) activ...
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| Publicado no: | Nat Neurosci |
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| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7257994/ https://ncbi.nlm.nih.gov/pubmed/31844313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0556-3 |
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