Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes

BACKGROUND: Tumor ablation techniques, like cryoablation, are successfully used in the clinic to treat tumors. The tumor debris remaining in situ after ablation is a major antigen depot, including neoantigens, which are presented by dendritic cells (DCs) in the draining lymph nodes to induce tumor-s...

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Detalles Bibliográficos
Publicado en:J Immunother Cancer
Main Authors: Raaijmakers, Tonke K, van den Bijgaart, Renske J E, den Brok, Martijn H, Wassink, Melissa, de Graaf, Annemarie, Wagenaars, Jori A, Nierkens, Stefan, Ansems, Marleen, Scheffer, Gert Jan, Adema, Gosse J
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Publishing Group 2020
Assuntos:
Basic Tumor Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254152/
https://ncbi.nlm.nih.gov/pubmed/32461350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000649
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