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Route of Administration of the TLR9 Agonist CpG Critically Determines the Efficacy of Cancer Immunotherapy in Mice

BACKGROUND: The TLR9 agonist CpG is increasingly applied in preclinical and clinical studies as a therapeutic modality to enhance tumor immunity. The clinical application of CpG appears, however, less successful than would be predicted from animal studies. One reason might be the different administr...

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Detalhes bibliográficos
Main Authors: Nierkens, Stefan, den Brok, Martijn H., Roelofsen, Thijs, Wagenaars, Jori A. L., Figdor, Carl G., Ruers, Theo J., Adema, Gosse J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791230/
https://ncbi.nlm.nih.gov/pubmed/20020049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008368
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