Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist

CpG DNA, a ligand for Toll-like receptor 9 (TLR9), has been one of the most promising immunotherapeutic agents. Although there are several types of potent humanized CpG oligodeoxynucleotide (ODN), developing “all-in-one” CpG ODNs activating both B cells and plasmacytoid dendritic cells forming a sta...

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Détails bibliographiques
Auteurs principaux: Kobiyama, Kouji, Aoshi, Taiki, Narita, Hirotaka, Kuroda, Etsushi, Hayashi, Masayuki, Tetsutani, Kohhei, Koyama, Shohei, Mochizuki, Shinichi, Sakurai, Kazuo, Katakai, Yuko, Yasutomi, Yasuhiro, Saijo, Shinobu, Iwakura, Yoichiro, Akira, Shizuo, Coban, Cevayir, Ishii, Ken J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2014
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939924/
https://ncbi.nlm.nih.gov/pubmed/24516163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319268111
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