Specific Conformational Dynamics and Expansion Underpin a Multi-Step Mechanism for Specific Binding of p27 with Cdk2/Cyclin A

The protein p27, a prominent regulatory protein in eukaryotes and an intrinsically disordered protein (IDP), regulates cell division by causing cell cycle arrest when bound in ternary complex with cyclin-dependent kinase (Cdk2) and cyclins (e.g., Cdk2/Cyclin A). We present an integrative study of p2...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Tsytlonok, Maksym, Hemmen, Katherina, Hamilton, George, Kolimi, Narendar, Felekyan, Suren, Seidel, Claus A.M., Tompa, Peter, Sanabria, Hugo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254055/
https://ncbi.nlm.nih.gov/pubmed/32088186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.02.010
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