Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation

p27(Kip1) is an intrinsically disordered protein (IDP) that inhibits cyclin-dependent kinase (Cdk)/cyclin complexes (e.g., Cdk2/cyclin A), causing cell cycle arrest. Cell division progresses when stably Cdk2/cyclin A-bound p27 is phosphorylated on one or two structurally occluded tyrosine residues a...

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Publicado no:Nat Commun
Main Authors: Tsytlonok, Maksym, Sanabria, Hugo, Wang, Yuefeng, Felekyan, Suren, Hemmen, Katherina, Phillips, Aaron H., Yun, Mi-Kyung, Waddell, M. Brett, Park, Cheon-Gil, Vaithiyalingam, Sivaraja, Iconaru, Luigi, White, Stephen W., Tompa, Peter, Seidel, Claus A. M., Kriwacki, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6459857/
https://ncbi.nlm.nih.gov/pubmed/30976006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09446-w
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