Quantification of mitochondrial DNA damage and copy number in circulating blood of patients with systemic sclerosis by a qPCR-based assay()()

BACKGROUND: Although not fully understood, oxidative stress has been implicated in the pathogenesis of different autoimmune diseases such as systemic sclerosis. Accumulating evidence indicates that oxidative stress can induce mitochondrial DNA (mtDNA) damage and variations in mtDNA copy number (mtDN...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:An Bras Dermatol
Hauptverfasser: Movassaghi, Shafieh, Jafari, Sara, Falahati, Kowsar, Ataei, Mitra, Sanati, Mohammad Hossein, Jadali, Zohreh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Sociedade Brasileira de Dermatologia 2020
Schlagworte:
Investigation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253925/
https://ncbi.nlm.nih.gov/pubmed/32307203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abd.2019.11.003
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