A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl(–)/H(+) transport cycle

Among coupled exchangers, CLCs uniquely catalyze the exchange of oppositely charged ions (Cl(–) for H(+)). Transport-cycle models to describe and explain this unusual mechanism have been proposed based on known CLC structures. While the proposed models harmonize with many experimental findings, gaps...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:eLife
Κύριοι συγγραφείς: Chavan, Tanmay S, Cheng, Ricky C, Jiang, Tao, Mathews, Irimpan I, Stein, Richard A, Koehl, Antoine, Mchaourab, Hassane S, Tajkhorshid, Emad, Maduke, Merritt
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: eLife Sciences Publications, Ltd 2020
Θέματα:
Structural Biology and Molecular Biophysics
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253180/
https://ncbi.nlm.nih.gov/pubmed/32310757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53479
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