A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl(–)/H(+) transport cycle

Among coupled exchangers, CLCs uniquely catalyze the exchange of oppositely charged ions (Cl(–) for H(+)). Transport-cycle models to describe and explain this unusual mechanism have been proposed based on known CLC structures. While the proposed models harmonize with many experimental findings, gaps...

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Udgivet i:eLife
Main Authors: Chavan, Tanmay S, Cheng, Ricky C, Jiang, Tao, Mathews, Irimpan I, Stein, Richard A, Koehl, Antoine, Mchaourab, Hassane S, Tajkhorshid, Emad, Maduke, Merritt
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Structural Biology and Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253180/
https://ncbi.nlm.nih.gov/pubmed/32310757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53479
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