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Substrate-driven conformational changes in ClC-ec1 observed by fluorine NMR

The CLC ‘Cl(−) channel' family consists of both Cl(−)/H(+) antiporters and Cl(−) channels. Although CLC channels can undergo large, conformational changes involving cooperativity between the two protein subunits, it has been hypothesized that conformational changes in the antiporters may be lim...

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Detalhes bibliográficos
Main Authors: Elvington, Shelley M, Liu, Corey W, Maduke, Merritt C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771095/
https://ncbi.nlm.nih.gov/pubmed/19745816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.259
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