(13)C NMR detects conformational change in the 100-kD membrane transporter ClC-ec1

CLC transporters catalyze the exchange of Cl(-) for H(+) across cellular membranes. To do so, they must couple Cl(-) and H(+) binding and unbinding to protein conformational change. However, the sole conformational changes distinguished crystallographically are small movements of a glutamate side ch...

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Udgivet i:J Biomol NMR
Main Authors: Abraham, Sherwin J., Cheng, Ricky C., Chew, Thomas A., Khantwal, Chandra M., Liu, Corey W., Gong, Shimei, Nakamoto, Robert K., Maduke, Merritt
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398623/
https://ncbi.nlm.nih.gov/pubmed/25631353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10858-015-9898-7
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