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Molecular Basis for Differential Anion Binding and Proton Coupling in the Cl(−)/H(+) Exchanger ClC-ec1

Cl(−)/H(+) transporters of the CLC superfamily form a ubiquitous class of membrane proteins that catalyze stoichiometrically coupled exchange of Cl(−) and H(+) across biological membranes. CLC transporters exchange H(+) for halides and certain polyatomic anions, but exclude cations, F(−), and larger...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Jiang, Tao, Han, Wei, Maduke, Merritt, Tajkhorshid, Emad
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4898471/
https://ncbi.nlm.nih.gov/pubmed/26880377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b12062
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