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The Coupled Proton Transport in the ClC-ec1 Cl(−)/H(+) Antiporter

Using a reactive molecular dynamics simulation methodology, the free energy barrier for water-mediated proton transport between the two proton gating residues Glu(203) and Glu(148) in the ClC-ec1 antiporter, including the Grotthuss mechanism of proton hopping, was calculated. Three different chlorid...

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Detalhes bibliográficos
Main Authors: Zhang, Yong, Voth, Gregory A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218320/
https://ncbi.nlm.nih.gov/pubmed/22098757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.10.021
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