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Multiscale Simulations Reveal Key Aspects of the Proton Transport Mechanism in the ClC-ec1 Antiporter

Multiscale reactive molecular dynamics simulations are used to study proton transport through the central region of ClC-ec1, a widely studied ClC transporter that enables the stoichiometric exchange of 2 Cl(–) ions for 1 proton (H(+)). It has long been known that both Cl(–) and proton transport occu...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Lee, Sangyun, Swanson, Jessica M.J., Voth, Gregory A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816718/
https://ncbi.nlm.nih.gov/pubmed/27028643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.02.014
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