Development of MAP4 kinase inhibitors as motor-neuron-protecting agents

Disease-causing mutations in many neurodegenerative disorders lead to proteinopathies that trigger endoplasmic reticulum (ER) stress. However, few therapeutic options exist for patients suffering from these diseases. Using an in vitro screening platform to identify compounds that protect human motor...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Chem Biol
Prif Awduron: Bos, Pieter H., Lowry, Emily R., Costa, Jonathon, Thams, Sebastian, Garcia-Diaz, Alejandro, Zask, Arie, Wichterle, Hynek, Stockwell, Brent R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253076/
https://ncbi.nlm.nih.gov/pubmed/31676236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.10.005
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