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Development of MAP4 kinase inhibitors as motor-neuron-protecting agents

Disease-causing mutations in many neurodegenerative disorders lead to proteinopathies that trigger endoplasmic reticulum (ER) stress. However, few therapeutic options exist for patients suffering from these diseases. Using an in vitro screening platform to identify compounds that protect human motor...

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Bibliografski detalji
Izdano u:Cell Chem Biol
Glavni autori: Bos, Pieter H., Lowry, Emily R., Costa, Jonathon, Thams, Sebastian, Garcia-Diaz, Alejandro, Zask, Arie, Wichterle, Hynek, Stockwell, Brent R.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253076/
https://ncbi.nlm.nih.gov/pubmed/31676236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.10.005
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