A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease selectively targeting motor neurons in the brain and spinal cord. The reasons for differential motor neuron susceptibility remain elusive. We developed a stem cell-based motor neuron assay to study cell-autonomous mechanisms causing...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Thams, Sebastian, Lowry, Emily Rhodes, Larraufie, Marie-Hélène, Spiller, Krista J., Li, Hai, Williams, Damian J., Hoang, Phuong, Jiang, Elise, Williams, Luis A., Sandoe, Jackson, Eggan, Kevin, Lieberam, Ivo, Kanning, Kevin C., Stockwell, Brent R., Henderson, Christopher E., Wichterle, Hynek
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318783/
https://ncbi.nlm.nih.gov/pubmed/30446391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.10.010
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