MT1-MMP deficiency leads to defective ependymal cell maturation, impaired ciliogenesis, and hydrocephalus

Hydrocephalus is characterized by abnormal accumulation of cerebrospinal fluid (CSF) in the ventricular cavity. The circulation of CSF in brain ventricles is controlled by the coordinated beating of motile cilia at the surface of ependymal cells (ECs). Here, we show that MT1-MMP is highly expressed...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Jiang, Zhixin, Zhou, Jin, Qin, Xin, Zheng, Huiling, Gao, Bo, Liu, Xinguang, Jin, Guoxiang, Zhou, Zhongjun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253023/
https://ncbi.nlm.nih.gov/pubmed/32229724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132782
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