MT1-MMP deficiency leads to defective ependymal cell maturation, impaired ciliogenesis, and hydrocephalus

Hydrocephalus is characterized by abnormal accumulation of cerebrospinal fluid (CSF) in the ventricular cavity. The circulation of CSF in brain ventricles is controlled by the coordinated beating of motile cilia at the surface of ependymal cells (ECs). Here, we show that MT1-MMP is highly expressed...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Jiang, Zhixin, Zhou, Jin, Qin, Xin, Zheng, Huiling, Gao, Bo, Liu, Xinguang, Jin, Guoxiang, Zhou, Zhongjun
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253023/
https://ncbi.nlm.nih.gov/pubmed/32229724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132782
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