MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development

Notch signalling controls the differentiation of haematopoietic progenitor cells (HPCs). Here, we show that loss of membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP14), a cell surface protease expressed in bone marrow stromal cells (BMSCs), increases Notch signalling in HPCs and specifically i...

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Detalhes bibliográficos
Main Authors: Jin, Guoxiang, Zhang, Fengju, Chan, Kui Ming, Xavier Wong, Hoi Leong, Liu, Baohua, Cheah, Kathryn S E, Liu, Xinguang, Mauch, Cornelia, Liu, Depei, Zhou, Zhongjun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117651/
https://ncbi.nlm.nih.gov/pubmed/21572390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.136
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