Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes

The worldwide prevalence of type 2 diabetes (T2D) is increasing. Despite normal to higher bone density, patients with T2D paradoxically have elevated fracture risk resulting, in part, from poor bone quality. Advanced glycation endproducts (AGEs) and inflammation as a consequence of enhanced receptor...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Eckhardt, Brittany A., Rowsey, Jennifer L., Thicke, Brianne S., Fraser, Daniel G., O’Grady, Katherine L., Bondar, Olga P., Hines, Jolaine M., Singh, Ravinder J., Thoreson, Andrew R., Rakshit, Kuntol, Lagnado, Anthony B., Passos, João F., Vella, Adrian, Matveyenko, Aleksey V., Khosla, Sundeep, Monroe, David G., Farr, Joshua N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253018/
https://ncbi.nlm.nih.gov/pubmed/32267250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135236
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