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Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes

The worldwide prevalence of type 2 diabetes (T2D) is increasing. Despite normal to higher bone density, patients with T2D paradoxically have elevated fracture risk resulting, in part, from poor bone quality. Advanced glycation endproducts (AGEs) and inflammation as a consequence of enhanced receptor...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Eckhardt, Brittany A., Rowsey, Jennifer L., Thicke, Brianne S., Fraser, Daniel G., O’Grady, Katherine L., Bondar, Olga P., Hines, Jolaine M., Singh, Ravinder J., Thoreson, Andrew R., Rakshit, Kuntol, Lagnado, Anthony B., Passos, João F., Vella, Adrian, Matveyenko, Aleksey V., Khosla, Sundeep, Monroe, David G., Farr, Joshua N.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253018/
https://ncbi.nlm.nih.gov/pubmed/32267250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135236
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