Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes

The worldwide prevalence of type 2 diabetes (T2D) is increasing. Despite normal to higher bone density, patients with T2D paradoxically have elevated fracture risk resulting, in part, from poor bone quality. Advanced glycation endproducts (AGEs) and inflammation as a consequence of enhanced receptor...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Eckhardt, Brittany A., Rowsey, Jennifer L., Thicke, Brianne S., Fraser, Daniel G., O’Grady, Katherine L., Bondar, Olga P., Hines, Jolaine M., Singh, Ravinder J., Thoreson, Andrew R., Rakshit, Kuntol, Lagnado, Anthony B., Passos, João F., Vella, Adrian, Matveyenko, Aleksey V., Khosla, Sundeep, Monroe, David G., Farr, Joshua N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253018/
https://ncbi.nlm.nih.gov/pubmed/32267250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135236
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