Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes

The worldwide prevalence of type 2 diabetes (T2D) is increasing. Despite normal to higher bone density, patients with T2D paradoxically have elevated fracture risk resulting, in part, from poor bone quality. Advanced glycation endproducts (AGEs) and inflammation as a consequence of enhanced receptor...

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Vydáno v:JCI Insight
Hlavní autoři: Eckhardt, Brittany A., Rowsey, Jennifer L., Thicke, Brianne S., Fraser, Daniel G., O’Grady, Katherine L., Bondar, Olga P., Hines, Jolaine M., Singh, Ravinder J., Thoreson, Andrew R., Rakshit, Kuntol, Lagnado, Anthony B., Passos, João F., Vella, Adrian, Matveyenko, Aleksey V., Khosla, Sundeep, Monroe, David G., Farr, Joshua N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253018/
https://ncbi.nlm.nih.gov/pubmed/32267250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135236
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