Discovery of a ZIP7 inhibitor from a Notch pathway screen

The identification of activating mutations in NOTCH1 in 50% of T cell acute lymphoblastic leukemia has generated interest in elucidating how these mutations contribute to oncogenic transformation and in targeting the pathway. A phenotypic screen identified compounds that interfere with trafficking o...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Nat Chem Biol
Κύριοι συγγραφείς: Nolin, Erin, Gans, Sara, Llamas, Luis, Bandyopadhyay, Somnath, Brittain, Scott M., Bernasconi-Elias, Paula, Carter, Kyle P., Loureiro, Joseph J., Thomas, Jason R., Schirle, Markus, Yang, Yi, Guo, Ning, Roma, Guglielmo, Schuierer, Sven, Beibel, Martin, Lindeman, Alicia, Sigoillot, Frederic, Chen, Amy, Xie, Kevin X., Ho, Samuel, Reece-Hoyes, John, Weihofen, Wilhelm A., Tyskiewicz, Kayla, Hoepfner, Dominic, McDonald, Richard I., Guthrie, Nicolette, Dogra, Abhishek, Guo, Haibing, Shao, Jian, Ding, Jian, Canham, Stephen M., Boynton, Geoff, George, Elizabeth L., Kang, Zhao B., Antczak, Christophe, Porter, Jeffery A., Wallace, Owen, Tallarico, John A., Palmer, Amy E., Jenkins, Jeremy L., Jain, Rishi K., Bushell, Simon M., Fryer, Christy J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2019
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7251565/
https://ncbi.nlm.nih.gov/pubmed/30643281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0200-7
Ετικέτες: Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

Παρόμοια τεκμήρια