Discovery of a ZIP7 inhibitor from a Notch pathway screen

The identification of activating mutations in NOTCH1 in 50% of T cell acute lymphoblastic leukemia has generated interest in elucidating how these mutations contribute to oncogenic transformation and in targeting the pathway. A phenotypic screen identified compounds that interfere with trafficking o...

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Publicado no:Nat Chem Biol
Principais autores: Nolin, Erin, Gans, Sara, Llamas, Luis, Bandyopadhyay, Somnath, Brittain, Scott M., Bernasconi-Elias, Paula, Carter, Kyle P., Loureiro, Joseph J., Thomas, Jason R., Schirle, Markus, Yang, Yi, Guo, Ning, Roma, Guglielmo, Schuierer, Sven, Beibel, Martin, Lindeman, Alicia, Sigoillot, Frederic, Chen, Amy, Xie, Kevin X., Ho, Samuel, Reece-Hoyes, John, Weihofen, Wilhelm A., Tyskiewicz, Kayla, Hoepfner, Dominic, McDonald, Richard I., Guthrie, Nicolette, Dogra, Abhishek, Guo, Haibing, Shao, Jian, Ding, Jian, Canham, Stephen M., Boynton, Geoff, George, Elizabeth L., Kang, Zhao B., Antczak, Christophe, Porter, Jeffery A., Wallace, Owen, Tallarico, John A., Palmer, Amy E., Jenkins, Jeremy L., Jain, Rishi K., Bushell, Simon M., Fryer, Christy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7251565/
https://ncbi.nlm.nih.gov/pubmed/30643281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0200-7
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