Tankyrase Inhibitor Sensitizes Lung Cancer Cells to Endothelial Growth Factor Receptor (EGFR) Inhibition via Stabilizing Angiomotins and Inhibiting YAP Signaling

YAP signaling pathway plays critical roles in tissue homeostasis, and aberrant activation of YAP signaling has been implicated in cancers. To identify tractable targets of YAP pathway, we have performed a pathway-based pooled CRISPR screen and identified tankyrase and its associated E3 ligase RNF146...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wang, Hui, Lu, Bo, Castillo, Johnny, Zhang, Yue, Yang, Zinger, McAllister, Gregory, Lindeman, Alicia, Reece-Hoyes, John, Tallarico, John, Russ, Carsten, Hoffman, Greg, Xu, Wenqing, Schirle, Markus, Cong, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946938/
https://ncbi.nlm.nih.gov/pubmed/27231341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.722967
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