Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

EGFR-mutant NSCLCs frequently respond to EGFR tyrosine kinase inhibitors (TKIs). However, the responses are not durable, and the magnitude of tumor regression is variable, suggesting the existence of genetic modifiers of EGFR dependency. Here, we applied a genome-wide CRISPR-Cas9 screening to identi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Zeng, Hao, Castillo-Cabrera, Johnny, Manser, Mika, Lu, Bo, Yang, Zinger, Strande, Vaik, Begue, Damien, Zamponi, Raffaella, Qiu, Shumei, Sigoillot, Frederic, Wang, Qiong, Lindeman, Alicia, Reece-Hoyes, John S, Russ, Carsten, Bonenfant, Debora, Jiang, Xiaomo, Wang, Youzhen, Cong, Feng
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2019
Gaiak:
Cancer Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927754/
https://ncbi.nlm.nih.gov/pubmed/31741433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50223
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