Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

EGFR-mutant NSCLCs frequently respond to EGFR tyrosine kinase inhibitors (TKIs). However, the responses are not durable, and the magnitude of tumor regression is variable, suggesting the existence of genetic modifiers of EGFR dependency. Here, we applied a genome-wide CRISPR-Cas9 screening to identi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Zeng, Hao, Castillo-Cabrera, Johnny, Manser, Mika, Lu, Bo, Yang, Zinger, Strande, Vaik, Begue, Damien, Zamponi, Raffaella, Qiu, Shumei, Sigoillot, Frederic, Wang, Qiong, Lindeman, Alicia, Reece-Hoyes, John S, Russ, Carsten, Bonenfant, Debora, Jiang, Xiaomo, Wang, Youzhen, Cong, Feng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2019
Pynciau:
Cancer Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927754/
https://ncbi.nlm.nih.gov/pubmed/31741433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50223
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