Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

EGFR-mutant NSCLCs frequently respond to EGFR tyrosine kinase inhibitors (TKIs). However, the responses are not durable, and the magnitude of tumor regression is variable, suggesting the existence of genetic modifiers of EGFR dependency. Here, we applied a genome-wide CRISPR-Cas9 screening to identi...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Zeng, Hao, Castillo-Cabrera, Johnny, Manser, Mika, Lu, Bo, Yang, Zinger, Strande, Vaik, Begue, Damien, Zamponi, Raffaella, Qiu, Shumei, Sigoillot, Frederic, Wang, Qiong, Lindeman, Alicia, Reece-Hoyes, John S, Russ, Carsten, Bonenfant, Debora, Jiang, Xiaomo, Wang, Youzhen, Cong, Feng
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2019
Teme:
Cancer Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927754/
https://ncbi.nlm.nih.gov/pubmed/31741433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50223
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