Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1

The intermediate filament protein keratin 14 (K14) provides vital structural support in basal keratinocytes of epidermis. Recent studies evidenced a role for K14-dependent disulfide bonding in the organization and dynamics of keratin IFs in skin keratinocytes. Here we report that knock-in mice harbo...

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Bibliographic Details
Published in:eLife
Main Authors: Guo, Yajuan, Redmond, Catherine J, Leacock, Krystynne A, Brovkina, Margarita V, Ji, Suyun, Jaskula-Ranga, Vinod, Coulombe, Pierre A
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2020
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250575/
https://ncbi.nlm.nih.gov/pubmed/32369015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53165
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