Runx3 prevents spontaneous colitis by directing the differentiation of anti-inflammatory mononuclear phagocytes

Mice deficient in the transcription factor Runx3 develop a multitude of immune system defects, including early onset colitis. This paper demonstrates that Runx3 is expressed in colonic mononuclear phagocytes (MNP), including resident macrophages (RM) and dendritic cell subsets (cDC2). Runx3 deletion...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Hantisteanu, Shay, Dicken, Yosef, Negreanu, Varda, Goldenberg, Dalia, Brenner, Ori, Leshkowitz, Dena, Lotem, Joseph, Levanon, Ditsa, Groner, Yoram
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250423/
https://ncbi.nlm.nih.gov/pubmed/32453801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0233044
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