Runx3 prevents spontaneous colitis by directing the differentiation of anti-inflammatory mononuclear phagocytes

Mice deficient in the transcription factor Runx3 develop a multitude of immune system defects, including early onset colitis. This paper demonstrates that Runx3 is expressed in colonic mononuclear phagocytes (MNP), including resident macrophages (RM) and dendritic cell subsets (cDC2). Runx3 deletion...

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Publicado en:PLoS One
Main Authors: Hantisteanu, Shay, Dicken, Yosef, Negreanu, Varda, Goldenberg, Dalia, Brenner, Ori, Leshkowitz, Dena, Lotem, Joseph, Levanon, Ditsa, Groner, Yoram
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250423/
https://ncbi.nlm.nih.gov/pubmed/32453801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0233044
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