Sustained Delivery of Acriflavine from the Suprachoroidal Space Provides Long Term Suppression of Choroidal Neovascularization

Hypoxia-inducible factor-1 (HIF-1) has been implicated in the pathogenesis of choroidal neovascularization (NV) and is an appealing target because it increases multiple pro-angiogenic proteins and their receptors. Acriflavine (ACF) binds HIF-1α and HIF-2α preventing binding to HIF-1β and inhibiting...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Biomaterials
Päätekijät: Hackett, Sean F., Fu, Jie, Kim, Yoo-Chun, Tsujinaka, Hiroki, Shen, Jikui, Silva, Raquel Lima e, Khan, Mahmood, Hafiz, Zibran, Wang, Tao, Shin, Matthew, Anders, Nicole M., He, Ping, Ensign, Laura M., Hanes, Justin, Campochiaro, Peter A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7249226/
https://ncbi.nlm.nih.gov/pubmed/32172031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2020.119935
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