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Bicalutamide Elicits Renal Damage by Causing Mitochondrial Dysfunction via ROS Damage and Upregulation of HIF-1α

Combined androgen blockade using bicalutamide (Bic) is a therapeutic choice for treating prostate cancer (PCa). However, even at regular clinical dosages, Bic frequently shows adverse effects associated with cardiovascular and renal damage. Previously, we found that Bic selectively damaged mesangial...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Chen, Kuan-Chou, Chen, Chang-Rong, Chen, Chang-Yu, Tzou, Kai-Yi, Peng, Chiung-Chi, Peng, Robert Y.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247665/
https://ncbi.nlm.nih.gov/pubmed/32403414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21093400
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