Proteomics Unravels Emodin Causes Liver Oxidative Damage Elicited by Mitochondrial Dysfunction

Emodin is one of the main active compounds in many Chinese traditional herbs. Due to its potential toxic effect on the liver, the possible injury mechanism needs to be explored. In the present study, we investigated liver injury mechanisms of emodin on rats by the technology of proteomics. Firstly,...

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Autori principali: Yinhuan Zhang, Xiaowei Yang, Zhixin Jia, Jie Liu, Xiaoning Yan, Yihang Dai, Hongbin Xiao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020-04-01
Serie:Frontiers in Pharmacology
Soggetti:
Emodin
liver injury
proteomics
mitochondrial dysfunction
redox homeostasis
Accesso online:https://www.frontiersin.org/article/10.3389/fphar.2020.00416/full
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