A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by endoplasmic reticulum aminopeptidase 1

Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims antigenic peptide precursors to generate mature antigenic peptides for presentation by major histocompatibility complex class I (MHCI) molecules and regulates adaptive immune responses. ERAP1 has been proposed to trim peptide precursors both in so...

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Pubblicato in:J Biol Chem
Autori principali: Mavridis, George, Arya, Richa, Domnick, Alexander, Zoidakis, Jerome, Makridakis, Manousos, Vlahou, Antonia, Mpakali, Anastasia, Lelis, Angelos, Georgiadis, Dimitris, Tampé, Robert, Papakyriakou, Athanasios, Stern, Lawrence J., Stratikos, Efstratios
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247305/
https://ncbi.nlm.nih.gov/pubmed/32184355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012976
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