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The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases

Antigenic peptides presented by the major histocompatibility complex class I (MHC-I) molecules for recognition by cytotoxic T-lymphocytes are processed by members of the oxytocinase sub-family of M1 aminopeptidases ERAP1, ERAP2, and IRAP. These three homologous zinc metallopeptidases trim N-terminal...

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Udgivet i:Front Immunol
Main Authors: Papakyriakou, Athanasios, Stratikos, Efstratios
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5545687/
https://ncbi.nlm.nih.gov/pubmed/28824657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00946
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