Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease

Exposure to chronic hyperglycemia because of diabetes mellitus can lead to development and progression of diabetic kidney disease (DKD). We recently reported that reduced superoxide production is associated with mitochondrial dysfunction in the kidneys of mouse models of type 1 DKD. We also demonstr...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Miyamoto, Satoshi, Zhang, Guanshi, Hall, David, Oates, Peter J., Maity, Soumya, Madesh, Muniswamy, Han, Xianlin, Sharma, Kumar
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247302/
https://ncbi.nlm.nih.gov/pubmed/32277051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011110
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