Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease

Exposure to chronic hyperglycemia because of diabetes mellitus can lead to development and progression of diabetic kidney disease (DKD). We recently reported that reduced superoxide production is associated with mitochondrial dysfunction in the kidneys of mouse models of type 1 DKD. We also demonstr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Miyamoto, Satoshi, Zhang, Guanshi, Hall, David, Oates, Peter J., Maity, Soumya, Madesh, Muniswamy, Han, Xianlin, Sharma, Kumar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247302/
https://ncbi.nlm.nih.gov/pubmed/32277051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011110
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