The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma

Glioblastoma (GBM) is the deadliest adult brain cancer, and all patients ultimately succumb to the disease. Radiation therapy (RT) provides survival benefit of 6 mo over surgery alone, but these results have not improved in decades. We report that radiation induces a glioma-initiating cell phenotype...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Bhat, Kruttika, Saki, Mohammad, Vlashi, Erina, Cheng, Fei, Duhachek-Muggy, Sara, Alli, Claudia, Yu, Garrett, Medina, Paul, He, Ling, Damoiseaux, Robert, Pellegrini, Matteo, Zemke, Nathan R., Nghiemphu, Phioanh Leia, Cloughesy, Timothy F., Liau, Linda M., Kornblum, Harley I., Pajonk, Frank
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7245100/
https://ncbi.nlm.nih.gov/pubmed/32358191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920154117
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