The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma

Glioblastoma (GBM) is the deadliest adult brain cancer, and all patients ultimately succumb to the disease. Radiation therapy (RT) provides survival benefit of 6 mo over surgery alone, but these results have not improved in decades. We report that radiation induces a glioma-initiating cell phenotype...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bhat, Kruttika, Saki, Mohammad, Vlashi, Erina, Cheng, Fei, Duhachek-Muggy, Sara, Alli, Claudia, Yu, Garrett, Medina, Paul, He, Ling, Damoiseaux, Robert, Pellegrini, Matteo, Zemke, Nathan R., Nghiemphu, Phioanh Leia, Cloughesy, Timothy F., Liau, Linda M., Kornblum, Harley I., Pajonk, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7245100/
https://ncbi.nlm.nih.gov/pubmed/32358191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920154117
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