The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma

Glioblastoma (GBM) is the deadliest adult brain cancer, and all patients ultimately succumb to the disease. Radiation therapy (RT) provides survival benefit of 6 mo over surgery alone, but these results have not improved in decades. We report that radiation induces a glioma-initiating cell phenotype...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Bhat, Kruttika, Saki, Mohammad, Vlashi, Erina, Cheng, Fei, Duhachek-Muggy, Sara, Alli, Claudia, Yu, Garrett, Medina, Paul, He, Ling, Damoiseaux, Robert, Pellegrini, Matteo, Zemke, Nathan R., Nghiemphu, Phioanh Leia, Cloughesy, Timothy F., Liau, Linda M., Kornblum, Harley I., Pajonk, Frank
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7245100/
https://ncbi.nlm.nih.gov/pubmed/32358191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920154117
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