ATG12 deficiency leads to tumor cell oncosis owing to diminished mitochondrial biogenesis and reduced cellular bioenergetics

In contrast to the “Warburg effect” or aerobic glycolysis earlier generalized as a phenomenon in cancer cells, more and more recent evidence indicates that functional mitochondria are pivotal for ensuring the energy supply of cancer cells. Here, we report that cancer cells with reduced autophagy-rel...

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Udgivet i:Cell Death Differ
Main Authors: Liu, He, He, Zhaoyue, Germič, Nina, Ademi, Hyrijie, Frangež, Živa, Felser, Andrea, Peng, Shuang, Riether, Carsten, Djonov, Valentin, Nuoffer, Jean-Marc, Bovet, Cédric, Mlinarič-Raščan, Irena, Zlobec, Inti, Fiedler, Martin, Perren, Aurel, Simon, Hans-Uwe
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244572/
https://ncbi.nlm.nih.gov/pubmed/31844253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0476-5
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