Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBPβ

Catabolism of the essential amino acid tryptophan is a key metabolic pathway contributing to the immunosuppressive tumor microenvironment and therefore a viable drug target for cancer immunotherapy. In addition to the rate-limiting enzyme indoleamine-2,3-dioxygenase-1 (IDO1), tryptophan catabolism v...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Kudo, Takumi, Prentzell, Mirja T., Mohapatra, Soumya R., Sahm, Felix, Zhao, Zhongliang, Grummt, Ingrid, Wick, Wolfgang, Opitz, Christiane A., Platten, Michael, Green, Edward W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239998/
https://ncbi.nlm.nih.gov/pubmed/32477324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00657
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