Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis

The catabolism of tryptophan to immunosuppressive and neuroactive kynurenines is a key metabolic pathway regulating immune responses and neurotoxicity. The rate-limiting step is controlled by indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO). IDO is expressed in antigen presenti...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Lanz, Tobias V., Williams, Sarah K., Stojic, Aleksandar, Iwantscheff, Simeon, Sonner, Jana K., Grabitz, Carl, Becker, Simon, Böhler, Laura-Inés, Mohapatra, Soumya R., Sahm, Felix, Küblbeck, Günter, Nakamura, Toshikazu, Funakoshi, Hiroshi, Opitz, Christiane A., Wick, Wolfgang, Diem, Ricarda, Platten, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5259766/
https://ncbi.nlm.nih.gov/pubmed/28117398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41271
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