Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma

Abnormal circulation in solid tumors results in hypoxia, which modulates both tumor intrinsic malignant properties as well as anti-tumor immune responses. Given the importance of hypoxia in glioblastoma (GBM) biology and particularly in shaping anti-tumor immunity, we analyzed which immunomodulatory...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Mohapatra, Soumya R., Sadik, Ahmed, Tykocinski, Lars-Oliver, Dietze, Jørn, Poschet, Gernot, Heiland, Ines, Opitz, Christiane A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905408/
https://ncbi.nlm.nih.gov/pubmed/31866995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02762
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