Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade

BACKGROUND: PD1/PDL1-directed therapies have been unsuccessful for multiple myeloma (MM), an incurable cancer of plasma cells in the bone marrow (BM). Therefore, other immune checkpoints such as extracellular adenosine and its immunosuppressive receptor should be considered. CD39 and CD73 convert ex...

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Publicat a:J Immunother Cancer
Autors principals: Yang, Rui, Elsaadi, Samah, Misund, Kristine, Abdollahi, Pegah, Vandsemb, Esten Nymoen, Moen, Siv Helen, Kusnierczyk, Anna, Slupphaug, Geir, Standal, Therese, Waage, Anders, Slørdahl, Tobias S, Rø, Torstein Baade, Rustad, Even, Sundan, Anders, Hay, Carl, Cooper, Zachary, Schuller, Alwin G, Woessner, Richard, Borodovsky, Alexandra, Menu, Eline, Børset, Magne, Sponaas, Anne Marit
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2020
Matèries:
Basic Tumor Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239696/
https://ncbi.nlm.nih.gov/pubmed/32409420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000610
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