Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade

BACKGROUND: PD1/PDL1-directed therapies have been unsuccessful for multiple myeloma (MM), an incurable cancer of plasma cells in the bone marrow (BM). Therefore, other immune checkpoints such as extracellular adenosine and its immunosuppressive receptor should be considered. CD39 and CD73 convert ex...

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Bibliografske podrobnosti
izdano v:J Immunother Cancer
Main Authors: Yang, Rui, Elsaadi, Samah, Misund, Kristine, Abdollahi, Pegah, Vandsemb, Esten Nymoen, Moen, Siv Helen, Kusnierczyk, Anna, Slupphaug, Geir, Standal, Therese, Waage, Anders, Slørdahl, Tobias S, Rø, Torstein Baade, Rustad, Even, Sundan, Anders, Hay, Carl, Cooper, Zachary, Schuller, Alwin G, Woessner, Richard, Borodovsky, Alexandra, Menu, Eline, Børset, Magne, Sponaas, Anne Marit
Format: Artigo
Jezik:Inglês
Izdano: BMJ Publishing Group 2020
Teme:
Basic Tumor Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239696/
https://ncbi.nlm.nih.gov/pubmed/32409420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000610
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