Modeling Favipiravir Antiviral Efficacy Against Emerging Viruses: From Animal Studies to Clinical Trials

In 2014, our research network was involved in the evaluation of favipiravir, an anti‐influenza polymerase inhibitor, against Ebola virus. In this review, we discuss how mathematical modeling was used, first to propose a relevant dosing regimen in humans, and then to optimize its antiviral efficacy i...

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Veröffentlicht in:CPT Pharmacometrics Syst Pharmacol
Hauptverfasser: Madelain, Vincent, Mentré, France, Baize, Sylvain, Anglaret, Xavier, Laouénan, Cédric, Oestereich, Lisa, Nguyen, Thi Huyen Tram, Malvy, Denis, Piorkowski, Géraldine, Graw, Frederik, Günther, Stephan, Raoul, Hervé, de Lamballerie, Xavier, Guedj, Jérémie
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239338/
https://ncbi.nlm.nih.gov/pubmed/32198838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12510
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