Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses

Favipiravir is an RNA polymerase inhibitor that showed strong antiviral efficacy in vitro and in small-animal models of several viruses responsible for hemorrhagic fever (HF), including Ebola virus. The aim of this work was to characterize the complex pharmacokinetics of favipiravir in nonhuman prim...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Madelain, Vincent, Guedj, Jérémie, Mentré, France, Nguyen, Thi Huyen Tram, Jacquot, Frédéric, Oestereich, Lisa, Kadota, Takumi, Yamada, Koichi, Taburet, Anne-Marie, de Lamballerie, Xavier, Raoul, Hervé
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192134/
https://ncbi.nlm.nih.gov/pubmed/27736754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01305-16
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